![]() Single to super king size bedding setsĪre you a duvet-hogger? Maybe you like to sleep starshaped (much to the annoyance of your other half)? However much space you need, we’ve got you covered with our range of bedding sets for all sizes. The fashionable trim on the duvet cover and pillowcase adds an extra little touch to this homely bedding set which will definitely earn its place in. This cute pom pom bedding set adds a quirky touch to any interior. Interest-free payments available on orders between £30 - £2000 with. We’ve got mermaids, unicorns, princess power and dinosaurs for the little ones and Harry Potter, the Avengers and super-cool star print for the tweens and teens. Free standard delivery on orders over £60. Tidying the kids’ bedrooms may feel like an endless, thankless routine but with a brand-spanking new kids bedding, you may finally be able to persuade them to do it themselves! Our wide range of children’s bedding offers something to suit the tastes of every child. Kids tidying their own room? Whatever next! ![]() From crisp and classic waffle whites in cool cotton to subtle grey and dusky pinks in beautiful velvet, your calm and collected needs are more than catered for in our classic range. If minimalism is your thing, then you’ll be interested in our diverse range of unadorned duvet sets. Beige Color and White Pom Pom, Duvet Cover With Button 100 Cotton Duvet Cover Twin Full Double Queen King Size Fringes Tassels duvet cover. Our bedding collection has everything from cool, monochrome stripes to vibrant blossoms to gorgeous floral bedding – we’ve got you covered. Echa un vistazo a nuestra selección de duvet cover king pom pom para ver las mejores piezas hechas a mano, únicas o personalizadas de nuestras tiendas. If your bed is the focal point of your boudoir (and rightly so) then you’re probably on the lookout for the perfect patterned bed set. Our bedding collection has everything you need to make sure night time is the right time for the perfect eight-hour slumber. The eye-catching and unique Pom Pom duvet set is available in a range of sumptuous shades and features a stunning fringe of tiny pom poms to draw the. This already wonderfully cosy time can only be made better by the addition of the perfect bed set. There can be few things better than snuggling under your duvet after a long, hard day at work. She was what Sage would call 'extra', and so were the folded grey satin throw edged with pale pink pom-poms, the duvet cover reminiscent of a spring meadow.
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![]() ![]() It increases pain transmission and is a very potent inflammatory protein. It is also a potent vasodilator (dilates blood vessels) which triggers more CGRP release and pain. What is Calcitonin Gene Related Peptide (CGRP), and how does CGRP relate to migraine?ĬGRP plays a strong role in neurogenic inflammation in the nervous system and is involved in the transmission of pain. Other migraine preventive therapies include neuromodulation devices, Botox injections, or alternative treatments such as vitamins and supplements, acupuncture, acupressure and pressure points, or yoga and meditation. ![]() The gepants (Nurtec, Qulipta) have also now received FDA approvals for migraine preventive treatment. Unfortunately, there were still many migraine patients that did not respond to these conventional options, or had side effects with them. These conventional migraine preventive treatments are still used, can be very effective, and are discussed in much greater detail here. Prior to 2018, all of the migraine preventive medication options had been “adopted” from other specialties.įor example, the 3 main categories of preventive medicines prior to 2018 were select evidence-based options within the anticonvulsant (anti-seizure), anti-depressant/anti-anxiety, and anti-hypertensive (blood pressure) medicine categories. So it finally happened! The 1 st migraine specific preventive medications FINALLY became available with the CGRP (calcitonin gene related peptide) monoclonal antibody (CGRP mAb) antagonists which first came to market in Spring of 2018. ![]() If you met at a conference and exchanged words about marketing strategies, and you’re emailing now to ask the recipient to review your new app for marketers, you’re connecting the right dots. Once again, this approach works best if your previous meeting is relevant to the topic at hand. Even if the recipient seems unlikely to remember, the fact that you did remember goes a long way toward establishing a rapport. Perhaps you connected briefly at a conference. If you’ve met the recipient before, it never hurts to say so. The sender may wonder whether you actually know the definition of brief. Don’t promise to keep it brief and then go on for paragraph after paragraph. There’s just one rule with this opener-if you’re going to use it, you’d better actually be brief. It, and the number of paragraphs in the email I see before me, tells me that the sender values my time and made an effort to keep things short and sweet. “I know you’re swamped, so I’ll be brief.” Saying you read an article is one thing, but mentioning the beach vacation photos you saw on Instagram will come off as creepy. ![]() There may be a hook there.) And also, don’t make your message too personal. (Unless maybe they write murder mysteries. It would be awkward to congratulate someone on the publication of their recent novel if you were writing to offer them a deal on life insurance. First, don’t use a personalized opener unless it actually relates to the topic you’re writing about. Include a sentence or two at the opening of your email to show you’re familiar with the recipient’s work, like this:Ĭongratulations on publishing 80 Shades of Green last week! I’m sure it’s thrilling to have the product of your creative labors out in the world. You don’t have to stalk someone on social media, but doing a little research can go a long way. If you’re writing a high-stakes email that needs to get results, it never hurts to do your homework. And if they pitch something that reflects the knowledge they’ve gained about my style and the topics I care about, it’s more likely to be something I can use. I have to admit, I admire their dedication to getting to know me, even if it comes with an ulterior motive. And, just when I think I’ve somehow earned a fan, I’ll get a letter from them asking me to accept a guest blog post or do some sort of cross-promotional content swap. In my work as an editor, I’ve had people follow me on Twitter or Facebook, commenting on and sharing every article I publish. Show that you value the recipient’s time by getting down to business right from the start. Although the response rate diminished slowly after that, talk to any busy person and they’ll tell you they prefer emails that are brief and get straight to the point. ![]() The email app Boomerang conducted a data study and found that emails between seventy-five and one hundred words in length had the best response rates. Here are my five favorite alternatives to the ubiquitous greeting. I’ve sent a few, too (we all do, from time to time!). (A rather conservative estimate, at that.) I’ve seen many an “I hope you’re doing well” cross my inbox. Grammarly helps you communicate confidently Write with GrammarlyĪs an entrepreneur, editor, and PR professional, I estimate that I’ve sent at least 73,000 business emails over the past twenty years. ![]() For example, if you’re in the U.K., you’ll see different content on Netflix than someone who is in Japan. Access blocked content: Many websites restrict content based on your geographical location.Changing your IP address ensures that data tracking isn’t connected to your normal IP address. The government, your ISP, the websites you visit and the search engines you use might track your online activity and location using your IP address. Privacy: Hiding your IP address helps mask online actions from who is doing it.Here are the most common reasons users may want to hide their original IP address. You might want to hide your current IP address for a number of purposes. Understanding these facts is critical to ensuring you maintain your device’s security and privacy while using one of the methods below to acquire a new IP address. If you aren’t comfortable tinkering with your router settings, it’s best to use a reliable, free VPN. Our guide will ensure you can implement this method, but it can be a hassle for those who aren’t comfortable with networking jargon. Too technical: If you don’t consider yourself tech-savvy, using a NAT firewall can sound intimidating.You can address this problem by selecting the right VPN tool, though. If you’re trying to hide your IP address to access geoblocked content, this can be a problem. This is also true for some free VPN services. Some free tools can be less effective: Using a proxy might not help you access geoblocked websites.Without encryption, hackers, the government and your internet service provider (ISP) can intercept your internet connection. Changing your IP doesn’t secure your network: Even when it changes your IP address, a free tool may or may not encrypt your connection.It’s critical to install an antivirus solution to protect your device when using a free tool and to ensure the tool you choose is reputable. Free tools can be dangerous: Many free VPNs or proxies are created by bad actors, and your device might even become vulnerable to malware attacks.Here’s what you should know before you hide your real IP address. While you can browse anonymously when you hide your actual IP address, there are things you should watch out for. Review Visit ProtonVPN 30-days money-back guarantee What Should I Know Before I Hide My IP Address for Free? However, you can get even better performance with a premium VPN, like ExpressVPN. The best method to hide your real IP address for free is to use a trustworthy free VPN (virtual private network) service, such as Proton VPN. We’ll also explain how you can verify if your IP address is truly hidden by a different IP address. In this article, we’ll share seven methods to hide your IP address (also called IP masking) for free, along with a few things you should know beforehand. If you’re wondering, “how can I hide my IP address for free,” we can help. Government censorship, geoblocking and increased cybercrime are key reasons for people to hide their IP addresses. Otherwise, if you’re open to investing in online privacy, ExpressVPN is an excellent VPN service. If you’re looking for free VPN options, consider Proton VPN, Windscribe and TunnelBear.Other methods can help hide your original IP but fail to secure your connection using encryption protocols.There are various methods to hide your IP address for free, but using a trustworthy VPN is the most secure and best option to protect your privacy.Last Updated: 22 Jun'23 T12:00:00+00:00 Facts checked by Vildana Bratic Key Takeaways: Hide My IP Address For Free MP4 Repair: How to Fix Corrupted Video Files in 2019.Best Choice Stellar Phoenix Data Recovery.How to Create a Strong Password in 2023: Secure Password Generator & 6 Tips for Strong Passwords.How to Securely Store Passwords in 2023: Best Secure Password Storage.Best Password Manager for Small Business. ![]()
![]() This ratio - which allows for easier comparisons of test results from different laboratories - is used if you take blood-thinning medications. A number lower than that range means blood clots more quickly than normal. A number higher than that range means it takes blood longer than usual to clot. The average time range for blood to clot is about 10 to 13 seconds. Prothrombin time test results can be presented in two ways. Home testing kits are available for people who have to take blood thinners for long periods and who have been trained in taking blood samples and testing them. You may receive the test result within minutes, while you are still in the exam room. ![]() In some clinics, a nurse will take a sample of your blood with a finger stick. If your provider sends your blood to an off-site laboratory, it may take several days to receive the results. If the laboratory analysis is done on-site, you could have your test results within hours. Your blood might be sent to a laboratory for analysis. Obtaining the blood sample for prothrombin time testing usually takes just a few minutes, like any other blood test. You might experience soreness or minor bruising at the site in the arm where your blood is drawn. Thus, we suggest a novel methodology to predict the targeted INR depending on individual patient characteristics.A prothrombin time test is similar to any other blood test. Using this approach, we determine the underlying causes behind thrombosis and bleeding persistence even for an INR in the normal range. We generate a population of patients with individual characteristics and assess their response to warfarin treatment by comparing the simulated INR and the corresponding developed clot height. It describes the inhibition of synthesis of the vitamin K dependent factors by warfarin in the liver. The action of warfarin is introduced by a Pharmacokinetics-Pharmacodynamics (PK-PD) sub-model. In this work we develop a model describing blood clotting during warfarin treatment. It tends to be in the range 2.0 – 3.0 in most conditions. The therapeutic target of INR varies from case to case depending on clinical indications. A high INR indicates a predisposition of the patient to bleeding, while a low INR shows that the warfarin dose is insufficient to prevent thromboembolic events. The action of warfarin is monitored using a blood test for the International Normalized Ratio (INR) which is based on prothrombin time measurement. Anticoagulant drugs such as warfarin are usually prescribed to prevent recurrent thrombosis. It can also detach and migrate with the flow resulting in pulmonary embolism. The resulting thrombus can partially or completely block blood circulation. Laboratoire Poncelet, UMI 2615 CNRS, Bolshoy Vlasyevskiy Pereulok 11, 119002 Moscow, Russiaĭeep venous thrombosis (DVT) is characterized by formation of blood clot within a deep vein. Hospices Civils de Lyon, Service de Pharmacologie Clinique, Lyon, France Lomonosov Moscow State University Leninskie gory 1, Moscow, Russiaįederal Research Clinical Center of Federal Medical & Biological Agency of Russia Orekhovy boulevard 28, Moscow, Russia Laboratoire de Mathématiques Appliquées et Informatique, Faculté des Sciences et Techniques Caddi Ayyad University, Marrakech, MoroccoĮcole Supérieure de Technologie, Cadi Ayyad University, Marrakech, Moroccoĭepartment of Biophysics, Faculty of Biology, M.V. ![]() INRIA Team Dracula, INRIA Antenne Lyon la Doua, Villeurbanne, France Laboratory of Study and Research in Applied Mathematics, Mohammadia School of Engineers Mohamed V university, Rabat, Morocco Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622 Villeurbanne, France Laboratoire de Biométrie et Biologie Evolutive, UMR 5558 CNRS University Lyon 1, 69376 Lyon, France ![]() Their last studio LP was 2017’s Hug of Thunder. The second extra is a cassette mixtape of unreleased instrumental compositions.Įarlier this year, Broken Social Scene issued the career-spanning Old Dead Young: B-Sides & Rarities set. Along with Nadler, 13 visual artists contributed to the graphic novel, which will be released along with a 10" vinyl single of “Lover’s Spit” that includes the original album version, as well as a stripped back B-side with Feist on vocals. The shows will mark the end of a two-and-a-half year hiatus forced. The book reimagines the LP into a series of intertwining vignettes. On April 20 and 21, Broken Social Scene will celebrate their 20th anniversary with two performances at the historic Massey Hall. ![]() They’ve paired with Z2 comics and writer Lonnie Nadler for Broken Social Scene: You Forgot It in People, The Graphic Novel. Find Broken Social Scene’s full schedule below.īroken Social Scene have also announced a new graphic novel in conjunction with the pivotal LP. Broken Social Scene at the Thalia Hall, Chicago, IL. The Toronto indie collective will celebrate the 20th anniversary of its breakthrough LP You Forgot It in People on the upcoming trek, performing the album in full at each concert. Now being redeveloped, sets for Todd Haynes’ 2002 Far From Heaven were built here, and it’s also hosted filming for Steven Spielberg’s War Of The Worlds, Michel Gondry’s Eternal Sunshine Of The Spotless Mind and The Bourne Ultimatum).Broken Social Scene have announced a string of North American tour dates kicking off in September. Studio filming was at the Peninsula at Bayonne Harbor, formerly the Military Ocean Terminal, a military base off the east coast of Bayonne in New York Bay. D2H & DJ Phat Mike present The 80s Dance Party. John Nash finally receives his Nobel Prize in Prudential Hall, New Jersey Performing Arts Center, 1 Center Street, Newark, New Jersey. Located in the basement of live music venue Thalia Hall Drink crafted punch cocktails and dig into. The grand mansion, where Nash leaves his top secret code-breaking results, is Tara Circle Irish Cultural Center, Alder Manor, 1061 North Broadway, Grey Oaks, in Yonkers, about 20 miles from NYC, which was seen also in The Royal Tenenbaums, Mona Lisa Smile and, um, Flesh For The Beast (from the acclaimed director of The Sexy Sixth Sense and Lord Of The G-Strings). The Governor’s ball was filmed in Lenfell Hall of Florham Mansion, Fairleigh Dickinson University, 285 Madison Avenue, in Madison, New Jersey. Thalia Hall is a historic landmark located in the Pilsen neighborhood of Chicago. The college was also used as the hospital. The famous ’Great Dome’ of ‘MIT’ is the Gould Memorial Library of Bronx Community College, 2155 Doctor Martin Luther King Junior Boulevard. Eventbrite - Thalia Hall presents Broken Social Scene with Jasmyn - Monday, Octoat Thalia Hall, Chicago, IL. The lab exterior is a wing of the Center for Molecular Medicine, 520 Belleville Avenue, in BelleVille, north of Newark, New Jersey. ![]() There is no ‘Wheeler Defense Laboratory’ at MIT (Massachusetts Institute of Technology) – and anyway, the film didn’t shoot in Cambridge. ‘Harvard University’ is Manhattan College, 4513 Manhattan College Parkway, Riverdale, New York, and Union Theological Seminary, 3041 Broadway, on New York’s Upper East Side, supplied further college scenes. The aerial shot of the Pentagon is real, but the ‘Pentagon’ office is Keating Hall, Fordham University, Rose Hill Campus, 441 East Fordham Road, in the Bronx. The house of John and Alicia Nash ( Jennifer Connelly) is 100 Grand Street, at Washington Street, Paulus Hook, in Jersey City. The filming is in New Jersey and around New York. Yes, it is Princeton University, New Jersey, where scenes were filmed at Holder Hall, County Road 571, during three separate visits, as the movie was shot largely in sequence. And James Horner’s score raises the possibility that perhaps Princeton University is going to hit an iceberg. Ron Howard’s film puts the struggle of brilliant mathematician John Nash ( Russell Crowe) through the Hollywood blender and – hey presto – nabs the Triumph over Adversity Oscars (Best Picture, Best Direction). Broken Social Scene Thalia Hall 9 de outubro de 2022. In the movies there’s no affliction, physical or mental, that can’t be overcome by sheer willpower and the lurve of a good woman. Get concert info and buy tickets to Broken Social Scenes upcoming concert at Thalia Hall in Chicago on out 09, 2022, all at Bandsintown. I also recommend running this software with nothing less than a P4 or Powerbook. Very simple.The instructions in the user's manual are very clear and easy to understand and they provide you with schematics to show you how to connect everything. Of course you have to install the software and allow your computer to detect the new hardware-the interface-but after that it's instant plug and play every time. That's why I give a 9 in the features department.īasically plug and play. Stanton Final Scratch has this feature I believe. Another feature that I think is very dope-but I haven't used yet-is being able to hook up a microphone to the interface,record your vocals into SSL, save them and then instantly be able to scratch and cut them.ALL ON THE FLY!!! The only thing I wish Rane would have added is a feature to allow you to record and convert to mp3 your vinyl collection all in SSL. The features are great-I love them.Especially being able to instantly make a double of the file being played.Just click and drag to the opposite virtual turntable and you have doubles. ![]() I highly recommend this or at least the upgraded version since this one is no longer being made. This program can do it all, the Ran Serato is a must buy item to have in your arsenal especially if you are just getting started you wont find an easier program to get cracking with. So load up those mp3’s that you love and listen to each day and start scratching and mixing them up. You will love these product and it will keep your creative juices flowing. Overall, it’s a great program, and even though its no longer being made you can get the upgraded version which has more features its called the Rane SL2. But its not watered down its just that easy to understand. The manual to this device is one of the easiest manuals ever, I only opened it just to look around at the features when I first got it and the manual really seemed to be watered down. But when I use it on my other laptop it works great, it worked great on my dell laptop great just that one time wasn’t so good. Getting started was a breeze and I think I may have only had 1 crash or freeze up with it and that was because I was using it on a very old dell laptop that just couldn’t handle it. Serato scratch Live is really easy to understand just start it up and get going. ![]() It actually still gets updated pretty frequently if you are subscribed to the mailing list. ![]() But for those of us who have used or have the SL 1 we know they they still provide support for it even though its no longer being manufactured. The Rane Serato Scratch Live is no longer being made, its actually been replace with its upgraded version the Rane SL 2. ![]() If you fall in love with, for example, the Blueberry Fruit Gems, there is no way to get a package of only Blueberry. As well, the Fruit Gems are currently only available in an assortment. To its credit, Jelly Belly has universally bulked every successful product it has made, so one assumes that after the “trial period” for the Fruit Gems is up, they will start releasing a ten pound box that will allow people to stock up at a more affordable and eco-friendly way. The Fruit Gems from Jelly Bellys are still very new and thus are only available in small packages like a 3.1 oz. Actually, they are quite good, but in the assortment – there are five flavors – some stand out more than others. These candies are marketed to taste precisely like various fruit flavors and they live up to that to varying degrees once you get by the sugar crystal coating. Jelly Belly fruit slices are approximately one and one-quarter inched in diameter by 3/8” thick. Jelly Belly fruit slices are little discs of sugar-coated gummy-style candies that are reminiscent of flattened gumdrops. With the Jelly Belly Sunkist Fruit Gems, they once again succeed with creating something that is new and different and tastes exactly like it is supposed to. But, as the company expands into new niche markets, they seem entirely determined to keep their quality standards very high. Jelly Belly will never be the candy company that is everything to everyone. In the case of Jelly Belly products, I have just completed consuming the last of the new products the company sent me and as they diversify away from “just” (had to put that in quotes because they are amazing!) jelly beans, it is hard not to wish I had stock in the company. That condition is even worse when one enjoys the products that they are reviewing. The saddest part of reviewing new foods is when they are gone. The Basics: Jelly Belly Sunkist Fruit Gems are a delightful way to get Vitamin C and may be one of the best non-jelly bean products Jelly Belly produces! The Bad: Seem a little expensive, No bulk (yet!) The Good: Sweet and tastes like the fruits they are supposed to, Presence of vitamin C If you want a second opinion, you can read Cybele’s take on them on her site.Pick up a ten pound case of the Sunkist Fruit Gems directly from Jelly ! Overall, I think they still get an OM, though I should note these also come individually wrapped in bulk bins, so you can pick and choose your favorite flavors. Blueberry was decent, and orange was nice but could have been punchier. I enjoyed the lemon and grapefruit flavored ones. It had a deep red fruit flavor and some noticeable tannins. Its flavor was more like blueberry jam or that blueberry-ish stuff that they’ll put on your pancakes at IHOP: blueberry-esque rather than like the fresh fruit. Here, too, the finish had an enjoyable bitterness to it.įinally, the maroon gem was blueberry. Grapefruit was pink and tasted just like grapefruit with its characteristic pithiness. There was a slight bitterness to the finish that I really enjoyed, as it made the flavor feel more genuine. Lemon had a bright citrus zestiness and a positively tangy lemon flavor. Compared to the Sunkist Orange Slices, which I also got as free samples, it was rather muted in flavor. Orange was mildly sweet with a mellow candied orange flavor that lacked any zesty bite or citrus sourness. It yielded instantly to my bite, and its exposed surfaces were perfectly smooth, with a glossy feel on my tongue. The Fruit Gems retained their original texture – a soft fruit-pate with a granulated sugar shell. ![]() This release altered the copyright text once again by finally updating the date, re-instating the Nintendo licensing (although no longer specifically mentioning Nintendo of America), and replacing Tengen's plain text logo with a Namco logo, based on the Namcot one that was in the original Famicom version. Later in 1993, the game was re-released again in North America, this time by Namco. Naturally, that means all mention of Nintendo was removed from the game. However, when Tengen lost official Nintendo licensing in 1989 due to a legal dispute, they chose to re-release Pac-Man on their own. ![]() The first Tengen release was officially licensed by Nintendo of America. Three separate revisions were released in North America alone, each containing slight changes primarily on the title screen depending on who published them and when. Unusually, Tengen did not bother to update the copyright date at all, retaining the 1984 date from the Famicom release, despite that being four years before Tengen's North American version released, and one year before the NES console itself was released in North America! They also re-organized the lines of copyright text slightly. When Tengen localized the Famicom version of Pac-Man for North America, they chose to overhaul the copyright text, adding the fact that the game was "Licensed by Nintendo of America", as well as replacing the unique "Namcot" logo with a simple plain text "Tengen" one. Yes, even a port of a game this basic has revisional differences. ![]() ALL RIGHTS RESERVEDĪdditionally, the name "HIROKI AOYAGI" is loaded into RAM at address $52, in order to distinguish between soft and hard resets (the high score is retained after a soft reset). ALL RIGHTS RESERVEDĬOPY RIGHT 1984 1993 NAMCO LTD. This one contains the following text:ĬOPY RIGHT 1984 1980 NAMCO LTD. Namco games often contain some generic copyright and/or credits text at the very beginning of their ROMs. ![]() Acute pulmonary vasoconstriction and thromboxane release during protamine reversal of heparin anticoagulation in awake sheep: Evidence for the role of reactive oxygen metabolites following nonimmunological complement activation. ![]() Morel DR, Lowenstein E, Nguyenduy T, et al. Prospective evaluation of risk of protamine reactions in patients with NPH insulin-dependent diabetes. A prospective study of the risk of an immediate adverse reaction to protamine sulfate during cardiopulmonary bypass surgery. Weiler JM, Gellhaus MA, Carter JG, et al. ![]() Pharmacology & Physiology in Anesthetic Practice. A comparison of the strength of binding of antithrombin III, protamine and poly(1-lysine) to heparin samples of different anticoagulant activities. Furthermore, compared with protamine, TDSP5 exhibited a much-reduced toxicity and thus an improved safety profile, as reflected by its reduced ability to activate the complement system and cross-react with the antiprotamine antibodies, which are 2 primary indices of protamine toxicity. As assessed by the anti-Xa assay, TDSP5 was as effective as, although less potent than, protamine in reversing the activity of Mono-Embolex (molecular weight 5000–7000) and 2 other different sizes (molecular weight of 30 d) of LMWH preparations. Additionally, these LMWP fractions could neutralize the activities of commercial LMWH. These LMWP fractions, particularly TDSP5, were effective and fully capable of neutralizing a broad spectrum of heparin-induced anticoagulant activities (ie, aPTT, anti-Xa, and anti-IIa activities). In this, the second article in this series, studies focused on in vitro evaluation of heparin/LMWH-neutralizing efficacy and putative toxicity. We had previously developed 2 low molecular weight protamine (LMWP) fractions (TDSP4 and TDSP5) from thermolysin-digested protamine as potential nontoxie, heparin-neutralizing agents. Patients undergoing anticoagulation with heparin or low molecular weight heparin (LMWH) require a superior antidote that possesses more selective biological actions and a better safety profile than protamine. |
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